CURRENT PROJECTS
Neuregulin3/ErbB4 Signaling During Nicotine Withdrawal
Neuregulin 3 is a member of the neuregulin family. SNPs in this gene and its cognate receptor, ErbB4 (HER4), have been implicated in nicotine dependence, but also in disorders known to be highly co-morbid with smoking, such as schizophrenia and ADHD. This project will involve multiple transgenic mouse models and experiments planned for this project will include electrophysiology, genomics, and animal behavior.
Neuregulin 3 is a member of the neuregulin family. SNPs in this gene and its cognate receptor, ErbB4 (HER4), have been implicated in nicotine dependence, but also in disorders known to be highly co-morbid with smoking, such as schizophrenia and ADHD. This project will involve multiple transgenic mouse models and experiments planned for this project will include electrophysiology, genomics, and animal behavior.
Astrocytic Control of Nicotine Withdrawal
Astrocytes are active participants of the synapse and can directly modulate the rewarding effects of drugs. This project utilizes a transgenic mouse possessing a dominant negative SNARE protein present only in astrocytes, which prevents their astrocytes from releasing gliotransmitters. Experiments planned for this project include electrophysiology, proteomics, and animal behavior.
Astrocytes are active participants of the synapse and can directly modulate the rewarding effects of drugs. This project utilizes a transgenic mouse possessing a dominant negative SNARE protein present only in astrocytes, which prevents their astrocytes from releasing gliotransmitters. Experiments planned for this project include electrophysiology, proteomics, and animal behavior.